The REAADER

The REAADER is the informational newsletter of Corgenix USA and Corgenix International. The primary purpose of the REAADER is to keep our customers up to date on the most recent findings in our area of expertise. Our REAADER newsletter covers a broad range of topics including articles on autoimmune disease, antiphospholipid syndrome, thrombosis and hemostasis evaluation.  

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Antiphospholipid Products

Anti-Cardiolipin (aCL) IgG/IgM Test Kit
Measures IgG and/or IgM anti-cardiolipin antibody levels for use in the diagnosis of anti-phospholipid syndrome and the risk assessment of increased blood clotting (thrombosis) in the general population.

Date

Title

March 2007 Overview: 5th International Congress on Autoimmunity
Oct. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part III: Assays to Test:  What, When and Why
Aug. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part II: Standardization: What it Means and How it Affects Results
June 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part I:  The Evolution of aPL Assay Development
Feb. 2003 New Multi-Point Calibration Method for Corgenix Anti-Phospholipid Assays
Dec. 2002 The 10th International Congress on Antiphospholipid Antibodies
June 2002 A Synopsis of The First Tutzing (Munich) Antiphospholipid Conference
April 2002 The Significance and Increasing Importance of IgA Antiphospholipid Antibodies
Aug. 2001 Evaluation of The Relative sensitivity and Accuracy of Four Antiphospholipid Antibody Assays
June 2001 The Significance Of Antiphospholipid Antibodies In A Patient With Angioimmunoblastic Lymphadenopathy (AILD) 
Apr. 2001 The Serologic Evaluation of Thrombosis: Comparative Performance of Four Antiphospholipid Antibody Assays
Feb. 2001 Evaluation of Antiphospholipid Antibody recovery of Matched Serum and Citrated Plasma Samples  On Four Antiphospholipid Assays
Dec. 2000 Practical Application of Suggested Antiphospholipid Testing Algorithm in aCL Negative, aPS Positive Antiphospholipid Syndrome Patient
Oct. 2000 The 9th International Symposium On Antiphospholipid Antibodies
Oct.  1999 A Practical Algorithm for the Lab Eval. of APA
June 1999 Comparative Clinical Performance of REAADS APA Tests: an Interpretive Tool
Apr.  1999 A Decade of APA Testing:  Update on Clinical Performance and Interpretive Ranges
Feb. 1999 Simultaneous Determination of aCL, aPS and aB2GPI Antibodies:  Correlation with the APS
Dec. 1998 The 8th International Symposium on Antiphospholipid Antibodies
Apr.  1998 Hypercoagulable States and Thrombotic Risk Assessment
Feb. 1998 APA Testing: A Current Review
Dec. 1996 Antiphospholipid Antibodies:  Mechanisms of Thrombosis
Feb. 1996 Antiphospholipid Antibody Testing:  Standardization and Clinical Interpretation of Results
Aug. 1995 Understanding Anticardiolipin Antibody Testing
Apr.  1995 Complexities of aCL Assay Standardization
Dec. 1994 The Sixth International Symposium on Antiphospholipid Antibodies
Oct.  1992 The Fifth International Symposium on Antiphospholipid Antibodies

 

Anti-Cardiolipin (aCL) IgA Test Kit
Measures IgA anti-cardiolipin antibody levels for use in the diagnosis of anti-phospholipid syndrome and the risk assessment of increased blood clotting (thrombosis) in the general population.   

Date

Title

March 2007 Overview: 5th International Congress on Autoimmunity
Oct. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part III: Assays to Test:  What, When and Why
Aug. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part II: Standardization: What it Means and How it Affects Results
June 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part I:  The Evolution of aPL Assay Development
Feb. 2003 New Multi-Point Calibration Method for Corgenix Anti-Phospholipid Assays
Feb. 2003 New Multi-Point Calibration Method for Corgenix Anti-Phospholipid Assays
Dec. 2002 The 10th International Congress on Antiphospholipid Antibodies
June 2002 A Synopsis of The First Tutzing (Munich) Antiphospholipid Conference
April 2002 The Significance and Increasing Importance of IgA Antiphospholipid Antibodies
June 2001 The Significance Of Antiphospholipid Antibodies In A Patient With Angioimmunoblastic Lymphadenopathy (AILD) 
Apr. 2001 The Serologic Evaluation of Thrombosis: Comparative Performance of Four Antiphospholipid Antibody Assays
Dec. 2000 Practical Application of Suggested Antiphospholipid Testing Algorithm in aCL Negative, aPS Positive Antiphospholipid Syndrome Patient
Oct. 2000 The 9th International Symposium On Antiphospholipid Antibodies
Oct.  1999 A Practical Algorithm for the Lab Eval. of APA
June 1999 Comparative Clinical Performance of REAADS APA Tests: an Interpretive Tool
Apr.  1999 A Decade of APA Testing:  Update on Clinical Performance and Interpretive Ranges
Feb. 1999 Simultaneous Determination of aCL, aPS and aB2GPI Antibodies:  Correlation with the APS
Dec. 1998 The 8th International Symposium on Antiphospholipid Antibodies
Apr.  1998 Hypercoagulable States and Thrombotic Risk Assessment
Feb. 1998 APA Testing: A Current Review
Dec. 1996 Antiphospholipid Antibodies:  Mechanisms of Thrombosis
Feb. 1996 Antiphospholipid Antibody Testing:  Standardization and Clinical Interpretation of Results
Aug. 1995 Understanding Anticardiolipin Antibody Testing
Apr.  1995 Complexities of aCL Assay Standardization
Dec. 1994 The Sixth International Symposium on Antiphospholipid Antibodies
Oct.  1992 The Fifth International Symposium on Antiphospholipid Antibodies

Anti-Phosphatidylserine (aPS) IgG/IgM Test Kit
Measures IgG and/or IgM anti-phosphatidylserine antibody levels for use in the diagnosis of anti-phospholipid syndrome and the risk assessment of increased blood clotting (thrombosis) in the general population.   Phosphatidylserine, a platelet and endothelial cell membrane lipid, participates in the coagulation cascade making it a more relevant antigen for use in anti-phospholipid testing. 

Date

Title

March 2007 Overview: 5th International Congress on Autoimmunity
Oct. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part III: Assays to Test:  What, When and Why
Aug. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part II: Standardization: What it Means and How it Affects Results
Feb. 2003 New Multi-Point Calibration Method for Corgenix Anti-Phospholipid Assays
Dec. 2002 The 10th International Congress on Antiphospholipid Antibodies
June 2002 A Synopsis of The First Tutzing (Munich) Antiphospholipid Conference
April 2002 The Significance and Increasing Importance of IgA Antiphospholipid Antibodies
Aug. 2001 Evaluation of The Relative sensitivity and Accuracy of Four Antiphospholipid Antibody Assays
June 2001 The Significance Of Antiphospholipid Antibodies In A Patient With Angioimmunoblastic Lymphadenopathy (AILD) 
Apr. 2001 The Serologic Evaluation of Thrombosis: Comparative Performance of Four Antiphospholipid Antibody Assays
Feb. 2001 Evaluation of Antiphospholipid Antibody recovery of Matched Serum and Citrated Plasma Samples  On Four Antiphospholipid Assays
Dec. 2000 Practical Application of Suggested Antiphospholipid Testing Algorithm in aCL Negative, aPS Positive Antiphospholipid Syndrome Patient
Oct. 2000 The 9th International Symposium On Antiphospholipid Antibodies
Oct.  1999 A Practical Algorithm for the Lab Eval. of APA
June 1999 Comparative Clinical Performance of REAADS APA Tests: an Interpretive Tool
Apr.  1999 A Decade of APA Testing:  Update on Clinical Performance and Interpretive Ranges
Feb. 1999 Simultaneous Determination of aCL, aPS and aB2GPI Antibodies:  Correlation with the APS
Dec. 1998 The 8th International Symposium on Antiphospholipid Antibodies
April 1998 Hypercoagulable States and Thrombotic Risk Assessment
Feb. 1998 APA Testing: A Current Review
Dec. 1996 Antiphospholipid Antibodies:  Mechanisms of Thrombosis
Aug. 1996 Cofactor Dependency of aPS Antibodies Correlates with Thrombosis in SLE Patients
June 1996 Relative to Cofactor Dependency, aPS Antibodies are Distinct and more Clinically Relevant than aCL Antibodies
Apr.  1996 Laboratory Determination of aPS Antibodies
June 1995 Determination, Prevalence, and Clinical Significance of aPS Antibodies
Feb. 1995 The Increasing Importance of aPS Antibodies

Anti-Phosphatidylserine (aPS) IgA Test Kit 
Measures IgA anti-phosphatidylserine antibody levels for use in the diagnosis of anti-phospholipid syndrome and the risk assessment of increased blood clotting (thrombosis) in the general population.   Phosphatidylserine, a platelet and endothelial cell membrane lipid, participates in the coagulation cascade making it a more relevant antigen for use in anti-phospholipid testing.

Date

Title

March 2007 Overview: 5th International Congress on Autoimmunity
Oct. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part III: Assays to Test:  What, When and Why
Aug. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part II: Standardization: What it Means and How it Affects Results
Feb. 2003 New Multi-Point Calibration Method for Corgenix Anti-Phospholipid Assays
Dec. 2002 The 10th International Congress on Antiphospholipid Antibodies
June 2002 A Synopsis of The First Tutzing (Munich) Antiphospholipid Conference
April 2002 The Significance and Increasing Importance of IgA Antiphospholipid Antibodies
Aug. 2001 Evaluation of The Relative sensitivity and Accuracy of Four Antiphospholipid Antibody Assays
June 2001 The Significance Of Antiphospholipid Antibodies In A Patient With Angioimmunoblastic Lymphadenopathy (AILD) 
Apr. 2001 The Serologic Evaluation of Thrombosis: Comparative Performance of Four Antiphospholipid Antibody Assays
Dec. 2000 Practical Application of Suggested Antiphospholipid Testing Algorithm in aCL Negative, aPS Positive Antiphospholipid Syndrome Patient
Oct. 2000 The 9th International Symposium On Antiphospholipid Antibodies
Apr.  2000 The Significance of IgA Anti-Phosphatidylserine (aPS) Antibodies

Anti-Beta 2 Glycoprotein I (B2GPI) IgG/IgM/IgA Test Kit 
Measures IgG, IgM, IgA anti-beta 2 glycoprotein I antibody levels for use in the diagnosis of anti-phospholipid syndrome and the risk assessment of increased blood clotting (thrombosis) in the general population.  Antibodies recognizing beta 2 glycoprotein I, a natural anticoagulant which serves as a necessary cofactor for most anti-phospholipid binding, are reported to be a more specific marker for thrombosis than antibodies detected by classic antiphospholipid ELISAs (anti-cardiolipin, anti-phosphatidylserine

Date

Title

Sept. 2007 Antiphospholipid Antibodies Risk Facts for Coronary Artery Disease
March 2007 Overview: 5th International Congress on Autoimmunity
Oct. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part III: Assays to Test:  What, When and Why
Aug. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part II: Standardization: What it Means and How it Affects Results
Feb. 2005 The Clinical Significance of IgG Autoantibodies to oxLDL/B2GPI Complex
Oct. 2004 The Clinical Significance of Circulating Oxidized Low-Density Lipoprotein Cholesterol-B2 Glycoprotein 1 (oxLDL-B2GP1) Complexes
Feb. 2004 The Emerging Importance of anti-B2 Glycoprotein and anti-Phosphatidylserine Antibodies in the Laboratory Evaluation of the Antiphospholipid Syndrome
Aug. 2004

Autoimmune-Mediated Atherosclerosis:  Autoantibodies Against oxLDL/ b2GPI Complexes

June 2004 Atherosclerosis in Systemic Autoimmune Diseases and Antiphospholipid Syndrome:  Possible Role in oxLDL/B2GPI Complexes as Atherogenic Autoantigens
Feb. 2004 The Emerging Importance of anti-B2 Glycoprotein 1 and anti-Phosphatidylserine Antibodies in the Laboratory Evaluation of the Antiphospholipid Syndrome
Dec. 2002 The 10th International Congress on Antiphospholipid Antibodies
Oct. 2002 Standardization of Anti-B2GPI Antibody ELISAs: Performance of 3 Commercial Assays on Selected Thrombosis Samples
June 2002 A Synopsis of The First Tutzing (Munich) Antiphospholipid Conference
April 2002 The Significance and Increasing Importance of IgA Antiphospholipid Antibodies
Aug. 2001 Evaluation of The Relative sensitivity and Accuracy of Four Antiphospholipid Antibody Assays
June 2001 The Significance Of Antiphospholipid Antibodies In A Patient With Angioimmunoblastic Lymphadenopathy (AILD) 
Apr. 2001 The Serologic Evaluation of Thrombosis: Comparative Performance of Four Antiphospholipid Antibody Assays
Feb. 2001 Evaluation of Antiphospholipid Antibody recovery of Matched Serum and Citrated Plasma Samples  On Four Antiphospholipid Assays
Dec. 2000 Practical Application of Suggested Antiphospholipid Testing Algorithm in aCL Negative, aPS Positive Antiphospholipid Syndrome Patient
Oct. 2000 The 9th International Symposium On Antiphospholipid Antibodies
Oct.  1999 A Practical Algorithm for the Lab Eval. of APA
June 1999 Comparative Clinical Performance of REAADS APA Tests: an Interpretive Tool
Apr.  1999 A Decade of APA Testing:  Update on Clinical Performance and Interpretive Ranges
Feb. 1999 Simultaneous Determination of aCL, aPS and aB2GPI Antibodies:  Correlation with the APS
Dec. 1998 The 8th International Symposium on Antiphospholipid Antibodies
Aug. 1998 Antibodies to B2GPI: Correlation with Thrombosis in SLE Pts.
June 1998 Prevalence of aB2GPI Antibodies in Healthy and Diseased Populations Detected by ELISA
April 1998 Hypercoagulable States and Thrombotic Risk Assessment
Feb. 1998 Anti-Phospholipid Antibody Testing: A Current Review
June 1997 Lab Evaluation of the Antiphospholipid Syndrome: the Significance Of Antibodies to b2-GPI
Dec. 1996 Antiphospholipid Antibodies:  Mechanisms of Thrombosis
Oct.  1996 b2-GPI and its Role in Anti-Phospholipid Testing

Anti-Prothrombin (IgG/ IgM) Antibody Test Kit  

Date

Title

Oct. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part III: Assays to Test:  What, When and Why
Aug. 2005 Anti-Phospholipid Testing 101 - Past, Present & Future Part II: Standardization: What it Means and How it Affects Results
Dec. 2004 Highlights from the 11th International Congress on Antiphospholipid Antibodies
Dec. 2002 The 10th International Congress on Antiphospholipid Antibodies
June 2002 A Synopsis of The First Tutzing (Munich) Antiphospholipid Conference
Aug. 2001 Evaluation of The Relative sensitivity and Accuracy of Four Antiphospholipid Antibody Assays
June 2001 The Significance Of Antiphospholipid Antibodies In A Patient With Angioimmunoblastic Lymphadenopathy (AILD) 
Apr. 2001 The Serologic Evaluation of Thrombosis: Comparative Performance of Four Antiphospholipid Antibody Assays
Feb. 2001 Evaluation of Antiphospholipid Antibody recovery of Matched Serum and Citrated Plasma Samples  On Four Antiphospholipid Assays
Oct. 2000 The 9th International Symposium On Antiphospholipid Antibodies
June 2000 Antibodies to Cofactors: Evaluation of anti-Prothrombin Antibodies by ELISA in Lupus Anticoagulant (LA) Plasma Samples
Feb. 2000 Antibodies to Cofactors: Significance of anti-Prothrombin Antibodies in the Antiphospholipid Syndrome
Aug. 2000 Multicentric Evaluation of anti-Prothrombin Antibodies by ELISA in Lupus Anticoagulant (LA) Positive Plasma Samples

 

Autoimmune Products

Anti-dsDNA Test Kit

An enzyme-linked immunosorbent assay (ELISA) for the semi-quantitative determination of IgG/IgM anti-dsDNA antibodies in human serum or plasma. As an aid in the diagnosis and management of systemic lupus erythematosus (SLE).

 

Date

Title

Oct. 2004 CDC and WHO Standardization Now Available in REAADS anti-dsDNA ELISA
Aug.1994 Clinical Significance & Detection of Antibodies to DNA

ANA ELISA
Screens for elevated IgG and IgM anti-nuclear antibody levels (specific for HEp-2 antigens) which are associated with various systemic rheumatic diseases including systemic lupus erythematosus and lupus variants, scleroderma, mixed connective tissue disease, Sjogren’s Syndrome, CREST, polymyositis and rheumatoid arthritis.   

Date

Title

Apr. 1994 Overview of the Immune System and Autoimmunity
Feb. 1992 Clinical Significance of ANA

 

Hemostasis Products

Protein C Antigen Test Kit
Measures total and free Protein C concentration used in the diagnosis of congenital or acquired Protein C deficiency.  

Date

Title

Aug. 2006 The Laboratory Evaluation of Protein C by ELISA
April 1998 Hypercoagulable States and Thrombotic Risk Assessment
Dec. 1997 Resistance To Activated Protein C (Factory V Leiden), Antiphospholipid Antibodies and Thrombosis
Aug. 1997 The Clinical Significance and Measurement of Protein C by ELISA in the Laboratory Assessment of Thrombosis
Dec. 1995 Clinical and Laboratory Significance Of Proteins C & S in Coagulation

Protein S Antigen Test Kit
Measures both total and free Protein S concentration used in the diagnosis of congenital or acquired Protein S deficiency.

Date

Title

Dec. 2007 New Role for Protein S and the Protein S-C4b Binding Protein Complex - a Link Between Autoimmunity and Thrombosis
Apr.  1998 Hypercoagulable States and Thrombotic Risk Assessment
Dec. 1997 Resistance To Activated Protein C (Factory V Leiden), Antiphospholipid Antibodies and Thrombosis
Oct. 1997 Clinical Significances and Laboratory Determination Of Protein S in The Assessment of Thrombosis
Aug. 1997 The Clinical Significance and Measurement of Protein C by ELISA in the Laboratory Assessment of Thrombosis
Dec. 1995 Clinical and Laboratory Significance Of Proteins C & S in Coagulation

Monoclonal Free Protein S Antigen Test Kit
Measures only free Protein S concentration used in the diagnosis of cogenital or acquired free Protein S deficiency.  

Date

Title

Aug. 1999 Direct Determination of Free PS by Monoclonal ELISA in the Evaluation of Hypercoagulability
Apr.  1998 Hypercoagulable States and Thrombotic Risk Assessment
Dec. 1997 Resistance To Activated Protein C (Factory V Leiden), Antiphospholipid Antibodies and Thrombosis
Oct. 1997 Clinical Significances and Laboratory Determination Of Protein S in The Assessment of Thrombosis

von Willebrand Factor Antigen Test Kit 
Measures total von Willebrand Factor (vWF) concentration (antigenic) for use in the diagnosis of Type I (quantitative) von Willebrand disease.  

Date

Title

Dec.2005 Complexity of the Laboratory Evaluation of von Willebrand Disease-The Use of Multiple Assay Enhances Diagnostic Accuracy
Apr. 2003 von Willebrand Disease Associated with Menorrhagia
Aug. 2002 The Clinical Significance of Elevated Von Willebrand Factor Levels
Feb. 2002 Classification of Type II vWD By Elisa Using Monoclonal Antibodies To Functional Epitopes of vWF 
Dec. 1999 The Laboratory Evaluation of von Willebrand Disease by ELISA
Dec. 1997 Resistance To Activated Protein C (Factory V Leiden), Antiphospholipid Antibodies and Thrombosis
Apr.  1997 Clinical Significance and Laboratory Determination of vWF

von Willebrand Factor Activity
Measures von Willebrand Factor (vWF) activity by employing a monoclonal antibody specific for the functional epitope of vWF and is used in the diagnosis of Type II (qualitative) von Willebrand disease.  

Date

Title

Dec.2005 Complexity of the Laboratory Evaluation of von Willebrand Disease-The Use of Multiple Assay Enhances Diagnostic Accuracy
Feb. 2004 The Utility of von Willebrand Factor Activity and Collagen Binding Assay ELISAs in Type 2 von Willebrand Disease
Apr. 2003 von Willebrand Disease Associated with Menorrhagia
Aug. 2002 The Clinical Significance of Elevated Von Willebrand Factor Levels
Feb. 2002 Classification of Type II vWD By Elisa Using Monoclonal Antibodies To Functional Epitopes of vWF 
Dec. 1999 The Laboratory Evaluation of von Willebrand Disease by ELISA

Collagen Binding
Measures the binding of von Willebrand Factor (vWF) to collagen.  This assay is currently available in the United States for investigational use only.

Dec.2005 Complexity of the Laboratory Evaluation of von Willebrand Disease-The Use of Multiple Assay Enhances Diagnostic Accuracy
Feb. 2004 The Utility of von Willebrand Factor Activity and Collagen Binding Assay ELISAs in Type 2 von Willebrand Disease
Dec. 2003 Clinical Utility of Collagen Binding Assay for von Willebrand Factor
   

Thrombin-Antithrombin III Complex
Measures thrombin-antithrombin III complex in human plasma.  Elevated plasma levels of TAT have been associated with a wide variety of thrombotic events.  

Date Title
Oct. 2003 Thrombin-Antithrombin III Complex, a Marker for Active Thrombosis

PIFA® Heparin/Platelet Factor 4 Rapid Assay
A rapid assay used to detect Heparin/PF4 antibodies as a means to help clinicians identify and treat patients at risk for Heparin Induced Thrombocytopenia or thrombosis.

Date Title
Feb. 2006 A Novel Rapid Testing for the Assessment of Heparin-Induced Thrombocytopenia:  the PIFA Heparin/PF4 Rapid Assay
Apr. 2005 The Diagnosis and Clinical Significance of Heparin-Induced Thrombocytopenia (HIT) Type II

Gastroenterology Products     

Hyaluronic Acid Test Kit

The Hyaluronic Acid (HA) quantitative Test kit is an enzyme linked binding protein assay for the quantitative determination of hyaluronic acid (HA) in human serum or plasma, The measurement of HA may be used to assess the degree of liver fibrosis and cirrhosis in chronic liver disease.

Date

Title

Dec. 2001 Serum Hyaluronic Acid (HA) in Patients with Chronic Hepatitis C Infection: A Non-Invasive Marker For Liver Fibrosis and Cirrhosis 

Oct. 2001

The Clinical Utility of Hyaluronic Acid (HA) in Rheumatologic and Liver Diseases

 Cardiovascular Products

AtherOx® Test Kit

The AtherOx™ (oxLDL-B2GPI antigen complex) ELISA Test Kit detects circulating complex formed by the interaction of oxidized low-density lipoprotein cholesterol (oxLDL) with B2 glycoprotein I (B2GPI) in human se